|本期目录/Table of Contents|

[1]王梦范,张丹丹.星点设计效应面法优化姜黄素微球的制备工艺[J].生物加工过程,2020,18(05):625-630.[doi:10.3969/j.issn.1672-3678.2020.05.013]
 WANG Mengfan,ZHANG Dandan.Optimized preparation of curcumin microspheres by central composite design-response surface method[J].Chinese Journal of Bioprocess Engineering,2020,18(05):625-630.[doi:10.3969/j.issn.1672-3678.2020.05.013]
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星点设计效应面法优化姜黄素微球的制备工艺()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
18
期数:
2020年05期
页码:
625-630
栏目:
出版日期:
2020-10-30

文章信息/Info

Title:
Optimized preparation of curcumin microspheres by central composite design-response surface method
文章编号:
1672-3678(2020)05-0625-06
作者:
王梦范张丹丹
青岛科技大学 化工学院,山东 青岛 266000
Author(s):
WANG MengfanZHANG Dandan
College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266000,China
关键词:
姜黄素 微球 乳化溶剂扩散法 星点设计效应面法
分类号:
R283.6
DOI:
10.3969/j.issn.1672-3678.2020.05.013
文献标志码:
A
摘要:
采用乳化溶剂扩散法来制备姜黄素微球。以包封率为评价指标,通过单因素试验法、星点设计效应面法优化制备处方工艺。最佳处方及工艺条件:乙基纤维素与姜黄素的质量比为20.04:1,吐温80用量为21.68 mg/mL,转速为600 r/min,搅拌时间为30 min以及水相和油相体积比为1.47:1。此条件下制备的姜黄素微球外形圆整,释放平稳,包封率高达93.66%,且制备工艺简单,效应面法建立的数学模型预测良好。
Abstract:
Curcumin microspheres were prepared by emulsion solvent diffusion method.The single factor experiment and central composite design-response surface method were used to select the optimum formulations and process conditions with the encapsulation efficiency as the evaluation criterion. Under the optimal formulation and process conditions,the mass ratio of ethyl cellulose to curcumin was 20.04:1,with the dosage of Tween80 21.68 mg/mL,rotating speed 600 r/min,stirring time 30 min,and the volume ratio of water phase to oil phase 1.47:1.Curcumin microspheres prepared under these conditions were round in shape,stable in release,with encapsulation efficiency as high as 93.66%.The preparation process was simple and the model established by response surface methodology delivered predictive accuracy.

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备注/Memo

备注/Memo:
收稿日期:2018-11-01修回日期:2020-05-17
基金项目:山东省重点研发计划(2018GSF119008); 青岛科技大学大学生创新创业计划(2018020005)
作者简介:王梦范(1993—),女,山东德州人,硕士研究生,研究方向:药物新剂型与新型给药系统; 张丹丹(联系人),副教授,E-mail:312685423@qq.com
引文格式:王梦范,张丹丹.星点设计效应面法优化姜黄素微球的制备工艺[J].生物加工过程,2020,18(5):625-630.
WANG Mengfan,ZHANG Dandan.Optimized preparation of curcumin microspheres by central composite design-response surface method[J].Chin J Bioprocess Eng,2020,18(5):625-630..
更新日期/Last Update: 2020-09-30