|本期目录/Table of Contents|

[1]万屹东,高有军,马江锋.生物法制备丁二酸的研究及产业化进展[J].生物加工过程,2020,18(05):583-591.[doi:10.3969/j.issn.1672-3678.2020.05.007]
 WAN Yidong,GAO Youjun,MA Jiangfeng.Progress in industrialization on succinic acid production by fermentation[J].Chinese Journal of Bioprocess Engineering,2020,18(05):583-591.[doi:10.3969/j.issn.1672-3678.2020.05.007]
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生物法制备丁二酸的研究及产业化进展()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
18
期数:
2020年05期
页码:
583-591
栏目:
出版日期:
2020-10-30

文章信息/Info

Title:
Progress in industrialization on succinic acid production by fermentation
文章编号:
1672-3678(2020)05-0583-09
作者:
万屹东12高有军12马江锋23
1. 常茂生物化学工程股份有限公司,江苏 常州 213034; 2. 江苏省生化手性工程技术研究中心,江苏 常州 213034; 3. 南京工业大学 生物与制药工程学院,江苏 南京 211800
Author(s):
WAN Yidong12GAO Youjun12MA Jiangfeng23
1. Changmao Biochemical Engineering Company Limited,Changzhou 213034,China; 2. Jiangsu Biochemical Chirality Engineering Technology Research Center,Changzhou 213034,China; 3. College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211800,China
关键词:
丁二酸 二氧化碳 可再生资源 生物制造
分类号:
TQ225.144【additional_page=630】
DOI:
10.3969/j.issn.1672-3678.2020.05.007
文献标志码:
A
摘要:
丁二酸是重要的C4平台化合物,采用生物发酵法、以可再生生物质资源和温室气体CO2等为原料的制备路线具有显著的优势,近年来成为国内外研究热点。目前已经有多个生物基丁二酸的产业化生产装置,但其制造成本仍然比石油基丁二酸的要高。鉴于此,本文中,笔者针对国内外生物基丁二酸研究和生产现状,从生产菌株、底物碳源、生产工艺三方面进行综述,发现现有微生物发酵法生产丁二酸仍然存在诸多技术屏障,生产的经济性有待进一步提高,并提出了未来几条经济性较高的丁二酸合成路线。
Abstract:
Succinate is an important chemical in C4 platform.Fermentation production of succinate has obvious advantages due to the use of renewable resources and fixation of greenhouse-gas CO2,gaining worldwide attention for the past few years.Recently,several industrial facilities have been established although the cost is still higher than that of petroleum-based production. Based on that,this review focuses on strains,substrates,processes to summarize the progress of research and industrialization on succinate production by fermentation,indicating that there are still several technical barriers in bio-based production of succinate,and the production economy needs to be further improved. Finally,several economical synthesis routes of succinate are proposed.

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备注/Memo

备注/Memo:
收稿日期:2019-07-26修回日期:2020-06-24
基金项目:江苏省重大科技项目(BE2016389)
作者简介:万屹东(1974—),男,江苏常州人,高级工程师,研究方向:发酵工程、分离工程; 马江锋(联系人),副研究员,E-mail:majiangfeng@njtech.edu.cn
引文格式:万屹东,高有军,马江锋.生物法制备丁二酸的研究及产业化进展[J].生物加工过程,2020,18(5):583-591.
WAN Yidong,GAO Youjun,MA Jiangfeng.Progress in industrialization on succinic acid production by fermentation[J].Chin J Bioprocess Eng,2020,18(5):583-591..
更新日期/Last Update: 2020-09-30