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[1]单莲云,任佳姝,王炳熙,等.纳米铜簇合成与应用在生物医药领域的研究进展[J].生物加工过程,2020,18(03):354-362.[doi:10.3969/j.issn.1672-3678.2020.03.013]
 SHAN Lianyun,REN Jiashu,WANG Bingxi,et al.Advances in the synthesis and applications of copper nanoclusters in biomedicine[J].Chinese Journal of Bioprocess Engineering,2020,18(03):354-362.[doi:10.3969/j.issn.1672-3678.2020.03.013]
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纳米铜簇合成与应用在生物医药领域的研究进展()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
18
期数:
2020年03期
页码:
354-362
栏目:
出版日期:
2020-05-30

文章信息/Info

Title:
Advances in the synthesis and applications of copper nanoclusters in biomedicine
文章编号:
1672-3678(2020)03-0354-09
作者:
单莲云任佳姝王炳熙陈金龙
中国药科大学 药学院,江苏 南京 210009
Author(s):
SHAN LianyunREN JiashuWANG BingxiCHEN Jinlong
School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China
关键词:
纳米铜簇 分析检测 应用进展
分类号:
TB383
DOI:
10.3969/j.issn.1672-3678.2020.03.013
文献标志码:
A
摘要:
纳米铜簇是由几个到几十个原子组成且尺寸接近费米波长的相对稳定聚集体,因其合成方法简单、生物相容性好及独特光、电、磁性质等优点,使其具有广泛的应用前景。本文中,笔者主要介绍了纳米铜簇的合成方法、优良的理化性质和应用进展,重点总结了近年来纳米铜簇在金属离子、生物分子、pH、温度、药物与抗菌等方面分析检测应用以及在化学催化、生物成像等领域的应用进展,以期为拓展铜簇在生物医药等领域的应用奠定基础。
Abstract:
In recent years,copper nanoclusters(Cu NCs)comprising of several to tens of copper atoms have received a great deal of attentions.Taking advantages of their amazing features such as simple preparations,excellent biocompatibility and unique optical,electrical as well as magnetic properties,Cu NCs are very promising materials in wide-field applications.In this review,we introduce the synthesis methods,excellent physicochemical properties and applications of Cu NCs and mainly focus on their applications in biomedicine fields including the detection of metal ions, biomolecule,pH,temperature,chemical catalysis and biological imaging have been reported,in order to expand the application of Cu NCs in biomedicine and other fields.

参考文献/References:

[1] JIN R C,ZENG C J,ZHOU M,et al.Atomically precise colloidal metal nanoclusters and nanoparticles:fundamentals and opportunities[J].Chem Rev,2016,116(18):10346-10413.
[2] MATHEW A,PRADEEP T.Noble metal clusters:applications in energy,environment,and biology[J].Part Part Syst Charact,2014,31(10):1017-1053.
[3] ZHANG L B,WANG E K.Metal nanoclusters:new fluorescent probes for sensors and bioimaging[J].Nano Today,2014,9(1):132-157.
[4] LIU J H,ZHANG Q M,FENG Y,et al.Solvent-switching gelation and orange-red emission of ultrasmall copper nanoclusters[J].ChemPhysChem,2016,17(2):225-231.
[5] ROTARU A,DUTTA S,JENTZSCH E,et al.Selective dsDNA-templated formation of copper nanoparticles in solution[J].Angew Chem Int Ed,2010,49(33):5665-5667.
[6] WANG H B,LI Y,BAI H Y,et al.Fluorescentdetermination of dopamine using polythymine-templated copper nanoclusters[J].Anal Lett,2018,58(18):2868-2877.
[7] GAO D P,ZHANG H Y,XU Y F,et al.Fluorescent copper nanoclusters as a nano-dye for DNA methyltransferase activity analysis and inhibitor screening[J].Anal Biochem,2018,559:5-10.
[8] RAJAMANIKANDAN R,ILANCHELIAN M.Protein-protected red emittive copper nanoclusters as a fluorometric probe for highly sensitive biosensing of creatinine[J].Anal Methods,2018,10(29):3666-3674.
[9] WU X M,ZHANG F,LI Y.Facile synthesis of near-infrared emitting dBSA-templated Cu nanoclusters for sensitive detection of heparin[J].J Mater Chem B,2018,6(34):5466-5475.
[10] ZHANG G M,WANG R R,SHI L H,et al.Aggregation/assembly induced emission based on silk fibroin-templated fluorescent copper nanoclusters for “turn-on” detection of S2-[J].Sensor Actuat B:Chem,2019,279:361-368.
[11] HE W J,GUI R J,JIN H,et al.Ratiometric fluorescence and visual imaging detection of dopamine based on carbon dots/copper nanoclusters dual-emitting nanohybrids[J].Talanta,2018,178:109-115.
[12] LIN L Y,HU Y F,ZHANG L L,et al.Photoluminescence light-up detection of zinc ion and imaging in living cells based on the aggregation induced emission enhancement of glutathione-capped copper nanoclusters[J].Biosens Bioelectron,2017,94:523-529.
[13] PATEL R,BOTHRA S,KUMAR R,et al.Pyridoxamine driven selective turn-off detection of picric acid using glutathione stabilized fluorescent copper nanoclusters and its applications with chemically modified cellulose strips[J].Biosens Bioelectron,2018,102:196-203.
[14] CUI M L,SONG G,WANG C,et al.Synthesis of cysteine-functionalized water-soluble luminescent copper nanoclusters and their application to the determination of chromium(VI)[J].Microchim Acta,2015,182(7/8):1371-1377.
[15] ZHOU T Y,YAO Q H,ZHAO T T,et al.One-pot synthesis of fluorescent DHLA-stabilized Cu nanoclusters for the determination of H2O2[J].Talanta,2015(7/8),141:80-85.
[16] HUANG Y Y,FENG H,LIU W D,et al.Luminescent aggregated copper nanoclusters nanoswitch controlled by hydrophobic interaction for real-time monitoring of acid phosphatase activity[J].Anal Chem,2016,88(23):11575-11583.
[17] WANG Z G,SUSHA A S,CHEN B K,et al.Poly(vinylpyrrolidone)supported copper nanoclusters:glutathione enhanced blue photoluminescence for application in phosphor converted light emitting devices[J].Nanoscale,2016,8(13):7197-7202.
[18] LING Y,ZHANG N,QU F,et al.Fluorescent detection of hydrogen peroxide and glucose with polyethyleneimine-templated Cu nanoclusters[J].Spectrochimi Acta Part A:Mol Biomol Spectrosc,2014,118:315-320.
[19] HU Y L,HE Y,HAN Y X,et al.Determination of the activity of alkaline phosphatase based on aggregation-induced quenching of the fluorescence of copper nanoclusters[J].Microchin Acta,2019,186:5.
[20] LI L,HUANG M,LIU X H,et al.Insitu generation of fluorescent copper nanoclusters embedded in monolithic eggshell membrane:properties and applications[J].Materials,2018,11(10):1913.
[21] BAO Z J,ZHANG K,JIAN J Y,et al.Strongly fluorescent cysteamine-coated copper nanoclusters as a fluorescent probe for determination of picric acid[J].Microchim Acta,2018,185(11):507.
[22] YUAN X,LUO Z T,ZHANG Q B,et al.Synthesis of highly fluorescent metal(Ag,Au,Pt,and Cu)nanoclusters by electrostatically induced reversible phase transfer[J].ACS Nano,2011,5(11):8800-8808.
[23] PAN S S,ZHANG X,LU W,et al.Plasmon-engineered anti-replacement synthesis of naked Cu nanoclusters with ultrahigh electrocatalytic activity[J].J Mater Chem A,2018,6(38):18687-18693.
[24] JAYASREE M,APARNA R S,ANJANA R R,et al.Fluorescence turn on detection of bilirubin using Fe(III)modulated BSA stabilized copper nanocluster; a mechanistic perception[J].Anal Chim Acta,2018,1031:152-160.
[25] WANG C X,CHENG H,SUN Y Q,et al.Rapidsonochemical synthesis of luminescent and paramagnetic copper nanoclusters for bimodal bioimaging[J].ChemNanoMat,2015,1(1):27-31.
[26] LU Y Z,CHEN W.Sub-nanometre sized metal clusters:from synthetic challenges to the unique property discoveries[J].Chem Soc Rev,2012,41(9):3594-3623.
[27] KWOK R T K,LEUNG C W T,LAM J W Y,et al.Biosensing by luminogens with aggregation-induced emission characteristics[J].Chem Soc Rev,2015,44(13):4228-4238.
[28] GOSWAMI N,YAO Q F,LUO Z T,et al.Luminescentmetal nanoclusters with aggregation-induced emission[J].J Phys Chem Lett,2016,7(6):962-975.
[29] CHEN J H,LIU J,FANG Z Y,et al.Random dsDNA-templated formation of copper nanoparticles as novel fluorescence probes for label-free lead ions detection[J].Chem Commun,2012,48(7):1057-1059.
[30] ZHANG H,GUAN Y N,LI X S,et al.Ultrasensitivebiosensor for detection of mercury(II)ions based on DNA-Cu nanoclusters and exonuclease III-assisted signal amplification[J].Anal Sci,2018,34(10):1155-1161.
[31] HUANG Y H,ZHANG H Q,XU X F,et al.Fast synthesis of porous copper nanoclusters for fluorescence detection of iron ions in water samples[J].Spectrochim Acta Part A:Mol Biomol Spectrosc,2018,202:65-69.
[32] QING Z H,MAO Z G,QING T P,et al.Visual andportable strategy for copper(II)detection based on a striplike poly(thymine)-caged and microwell-printed hydrogel[J].Anal Chem,2014,86(22):11263-11268.
[33] HU X,MAO X X,ZHANG X D,et al.One-step synthesis of orange fluorescent copper nanoclusters for sensitive and selective sensing of Al3+ ions in food samples[J].Sensor Actuat B:Chem,2017,247:312-318.
[34] BOONMEE C,PROMARAK V,TUNTULANI T,et al.Cysteamine-capped copper nanoclusters as a highly selective turn-on fluorescent assay for the detection of aluminum ions[J].Talanta,2018,178:796-804.
[35] HAN B Y,HU X X,XU J,et al.Lysozyme-directed synthesis of yellow-emitting copper nanoclusters for cobalt Ions(Co2+)sensing[J].J Nanosci Nanotechnol,2018,18(11):7933-7938.
[36] ZHONG Y P,WANG Q P,HE Y,et al.A novel fluorescence and naked eye sensor for iodide in urine based on the iodide induced oxidative etching and aggregation of Cu nanoclusters[J].Sensor Actuat B:Chem,2015,209:147-153.
[37] CANG J S,WANG C W,CHEN P C,et al.Control of pH for separated quantitation of nitrite and cyanide ions using photoluminescent copper nanoclusters[J].Anal Methods,2017,9(36):5254-5259.
[38] ZHANG S Y,CHEN C,QIN X F,et al.Ultrasensitive detection of trypsin activity and inhibitor screening based on the electron transfer between phosphorescence copper nanocluster and cytochrome c[J].Talanta,2018,189:92-99.
[39] BU X N,FU Y X,JIN H,et al.Specific enzymatic synthesis of 2,3-diaminophenazine and copper nanoclusters used for dual-emission ratiometric and naked-eye visual fluorescence sensing of choline[J].New J Chem,2018,42(21):17323-17330.
[40] HAN A L,XIONG L,HAO S J,et al.Highlybright self-assembled copper nanoclusters:a novel photoluminescent probe for sensitive detection of histamine[J].Anal Chem,2018,90(15):9060-9067.
[41] WANG C,YAO Y G,SONG Q J.Interfacial synthesis of polyethyleneimine-protected copper nanoclusters:size-dependent tunable photoluminescence,pH sensor and bioimaging[J].Colloids Surfaces B:Biointerfaces,2016,140:373-381.
[42] ZHANG G M,XU T,DU H Z,et al.A reversible fluorescent pH-sensing system based on the one-pot synthesis of natural silk fibroin-capped copper nanoclusters[J].J Mater Chem C,2016,4(16):3540-3545.
[43] ZHOU T Y,XU W,YAO Q H,et al.Highly fluorescent copper nanoclusters as a probe for the determination of pH[J].Methods Appl Fluoresc,2015,3(4):44002.
[44] YE J,DONG X W,JIANG H,et al.An intracellular temperature nanoprobe based on biosynthesized fluorescent copper nanoclusters[J].J Mater Chem B,2017,5(4):691-696.
[45] HUANG H,LI H,WANG A J,et al.Green synthesis of peptide-templated fluorescent copper nanoclusters for temperature sensing and cellular imaging[J].Analyst,2014,139(24):6536-6541.
[46] WANG L,MIAO H,ZHONG D,et al.Synthesis of dopamine-mediated Cu nanoclusters for sensing and fluorescentcoding[J].Anal Methods,2016,8(1):40-44.
[47] WANG B Q,GUI R J,JIN H,et al.Red-emitting BSA-stabilized copper nanoclusters acted as a sensitive probe for fluorescence sensing and visual imaging detection of rutin[J].Talanta,2018,178:1006-1010.
[48] MIAO H,ZHONG D,ZHOU Z N,et al.Papain-templated Cu nanoclusters:assaying and exhibiting dramatic antibacterial activity cooperating with H2O2[J].Nanoscale,2015,7(45):19066-19072.
[49] HOYT R A,MONTEMORE M M,KAXIRAS E.Nonadiabatic hydrogen dissociation on copper nanoclusters[J].J Phys Chem Lett,2018,9(18):5339-5343.
[50] HE L L,WANG X,WU X X,et al.Protein damage and reactive oxygen species generation induced by the synergistic effects of ultrasound and methylene blue[J].Spectrochim Acta Part A:Mol Biomol Spectrosc,2015,134:361-366.
[51] ROJAS J C,BRUCHEY A K,GONZALEZ-LIMA F.Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue[J].Prog Neurobiol,2012,96(1):32-45.
[52] GOZZELINO R,JENEY V,SOARES M P.Mechanisms of cell protection by heme oxygenase-1[J].Annu Rev Pharmacol Toxicol,2010,50(1):323-354.
[53] JIA X F,YANG X,LI J,et al.Stable Cu nanoclusters:from an aggregation-induced emission mechanism to biosensing and catalytic applications[J].Chem Commun,2014,50(2):237-239.
[54] PRAKASH K T,SINGH N,VENKATESH V.Synthesis of novel luminescent copper nanoclusters with substituent driven self-assembly and aggregation induced emission(AIE)[J].Chem Commun,2019,55(3):322-325.

备注/Memo

备注/Memo:
收稿日期:2019-02-22修回日期:2019-04-11
基金项目:中央高校基本业务费重点项目(2632019ZD18); 国家自然科学基金青年基金(21350161)
作者简介:单莲云(1996—),女,江苏南通人,硕士研究生,研究方向:功能纳米探针; 陈金龙(联系人),副教授,chenjl_4@hotmail.com
引文格式:单莲云,任佳姝,王炳熙,等.纳米铜簇合成与应用在生物医药领域的研究进展[J].生物加工过程,2020,18(3):354-362.
SHAN Lianyun,REN Jiashu,WANG Bingxi,et al.Advances in the synthesis and applications of copper nanoclusters in biomedicine[J].Chin J Bioprocess Eng,2020,18(3):354-362..
更新日期/Last Update: 2020-05-30