|本期目录/Table of Contents|

[1]解晓芬,吕永博,葛黎明,等.氧化直链淀粉对姜黄素的增溶作用[J].生物加工过程,2020,18(03):332-339.[doi:10.3969/j.issn.1672-3678.2020.03.010]
 XIE Xiaofen,L? Yongbo,GE Liming,et al.The solubilization of curcumin by oxidized amylose[J].Chinese Journal of Bioprocess Engineering,2020,18(03):332-339.[doi:10.3969/j.issn.1672-3678.2020.03.010]
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氧化直链淀粉对姜黄素的增溶作用()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
18
期数:
2020年03期
页码:
332-339
栏目:
出版日期:
2020-05-30

文章信息/Info

Title:
The solubilization of curcumin by oxidized amylose
文章编号:
1672-3678(2020)03-0332-08
作者:
解晓芬吕永博葛黎明李德富穆畅道
四川大学 化学工程学院,四川 成都 610065
Author(s):
XIE XiaofenL? YongboGE LimingLI DefuMU Changdao
School of Chemical Engineering,Sichuan University,Chengdu 610065,China
关键词:
氧化多糖 直链淀粉 姜黄素 包合物 增溶作用
分类号:
Q539;R944
DOI:
10.3969/j.issn.1672-3678.2020.03.010
文献标志码:
A
摘要:
姜黄素具有抗菌、抗炎、抗氧化和抗肿瘤等多种生物活性,但其不溶于水的性质大大限制了其临床应用。采用H2O2氧化法制备氧化直链淀粉,系统研究氧化直链淀粉对姜黄素在水中的增溶作用、氧化直链淀粉-姜黄素包合物水溶液的稳定性和抗氧化活性。结果表明,直链淀粉被氧化后由于羧基和醛基的引入,在水中的溶解度得到了大幅度的提升。氧化直链淀粉通过与姜黄素形成包合物而大大提高其水溶性,其增溶倍数最高可达3 720倍,增溶作用非常显著。而且,氧化直链淀粉-姜黄素包合物水溶液的老化现象减缓,水溶液的稳定性得到了改善。由于具有更高的姜黄素含量和稳定性,氧化直链淀粉-姜黄素包合物的水溶液呈现出更好的抗氧化活性。本研究表明氧化直链淀粉是姜黄素的有效增溶载体,具有应用前景。
Abstract:
Curcumin has many biological activities,such as antibacterial activity,anti-inflammatory,anti-oxidation and anti-tumor.However,its clinical application is limited by the water-insoluble nature.We prepared oxidized amylose by hydrogen peroxide oxidation.The solubilization of curcumin by oxidized amylose,the stability and antioxidant activity of the aqueous solution of oxidized amylose-curcumin inclusion complex were studied.The solubility of amylose in water was greatly improved after oxidation due to the introduction of carboxyl and aldehyde groups.Oxidized amylose improved the water solubility of curcumin by forming inclusion complex,and the solubilization ratio increased up to 3 720 times.Moreover,the aging phenomenon of the aqueous solution of oxidized amylose-curcumin inclusion complex was reduced,and the stability of the aqueous solution was improved.The aqueous solution of oxidized amylose-curcumin inclusion complex showed better antioxidant activity due to the higher content of curcumin.Overall,the oxidized amylose is an effective solubilizing carrier of curcumin and has a promising application prospect.

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相似文献/References:

[1]訾娅鑫,雷金凤,徐志朗,等.多糖的氧化改性及在生物医药领域的应用[J].生物加工过程,2018,16(01):31.[doi:10.3969/j.issn.1672-3678.2018.01.004]
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备注/Memo

备注/Memo:
收稿日期:2020-02-23修回日期:2020-03-06
基金项目:四川省国际科技创新合作项目(2019YFH0110); 四川省重点研发计划(SCST18ZDYF1426)
作者简介:解晓芬(1993—),女,甘肃临夏人,硕士研究生,研究方向:生物化工; 吕永博(联系人),工程师,E-mail:lvyongbojtr@126.com; 李德富(联系人),副教授,E-mail:lidefu@scu.edu.cn
引文格式:解晓芬,吕永博,葛黎明,等.氧化直链淀粉对姜黄素的增溶作用[J].生物加工过程,2020,18(3):332-339.
XIE Xiaofen,Lü Yongbo,GE Liming,et al.The solubilization of curcumin by oxidized amylose[J].Chin J Bioprocess Eng,2020,18(3):332-339..
更新日期/Last Update: 2020-05-30