|本期目录/Table of Contents|

 GAO Jing,PENG Mengxue,LIANG Zhihong.Research progress of quorum sensing signal molecules and quorum sensing quenching in fungi[J].Chinese Journal of Bioprocess Engineering,2020,18(02):214-223.[doi:10.3969/j.issn.1672-3678.2020.02.011]





Research progress of quorum sensing signal molecules and quorum sensing quenching in fungi
中国农业大学 北京食品营养与人类健康高精尖创新中心 食品科学与营养工程学院,北京 100083
GAO JingPENG MengxueLIANG Zhihong
College of Food Science& Nutritional Engineering,Beijing Advance Innovation Center for Food Nutrition and Human Health, China Agricultural University,Beijing 100083,China
真菌 群体感应信号分子 法尼醇 脂氧合物 群体感应猝灭
群体感应(quorum sensing,QS)是微生物中普遍存在的细胞间通讯系统,细菌中的研究较为深入,近年来在真菌中也有发现。微生物通过向环境释放可扩散的群体感应信号分子(quorum sensing molecules,QSM)来感知群体密度并调控自身的生理行为,以适应环境的变化。目前验证的真菌QSM包括醇类、脂氧合物、小分子肽以及某些挥发性物质。除影响种内的生长发育及次级代谢物产生外,真菌QSM还与其侵染能力、致病性和毒素产生有关,为了抵御QS的不利影响,生物共同进化过程中相应地出现了群体感应淬灭(quorum quenching,QQ)机制,QQ能够修饰或抑制QSM的合成从而破坏QS。本文中,笔者对国内外近10年来对真菌QSM种类、生理作用及QQ的研究进展进行综述,以期为深化真菌群体感应机制的研究提供参考。
Quorum sensing(QS)is a ubiquitous intercellular communication system in microorganisms.Microbes release diffusible quorum sensing molecules(QSM)to the environment to sense population density and regulate their own physiological behaviors to adapt to changes in the environment.Currently verified fungal QSMs include alcohols,lipoxylates,small molecule peptides,and certain volatile substances.In addition to affecting the growth and development of the species and the production of secondary metabolites,fungal QSM is also related to its infectivity,pathogenicity,and toxin production.In order to resist the adverse effects of QS,quorum induction quenching has occurred during the co-evolution of organisms.Quorum quenching(QQ)mechanism can modify or inhibit the synthesis of QSM to destroy QS.This article reviews the species,physiological effects,and QQ research progress of fungal QSM in the past 10 years at home and abroad,with a view to providing a reference for further research on fungal quorum sensing mechanisms.


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作者简介:高婧(1997—)(ORCID:0000-0003-1180-8833),女,内蒙古人,硕士研究生,研究方向:营养与食品安全; 梁志宏(联系人)(ORCID:0000-0002-4205-5021),副教授, E-mail:lzh105@cau.edu.cn
GAO Jing,PENG Mengxue,LIANG Zhihong.Research progress of quorum sensing signal molecules and quorum sensing quenching in fungi[J].Chin J Bioprocess Eng,2020,18(2):214-223..
更新日期/Last Update: 2020-03-31