|本期目录/Table of Contents|

[1]逄晓阳,朱青,芦晶,等.乳酸菌群体感应系统研究进展[J].生物加工过程,2020,18(02):141-149.[doi:10.3969/j.issn.1672-3678.2020.02.002]
 PANG Xiaoyang,ZHU Qing,LU Jing,et al.Progress in quorum sensing system of lactic acid bacteria[J].Chinese Journal of Bioprocess Engineering,2020,18(02):141-149.[doi:10.3969/j.issn.1672-3678.2020.02.002]
点击复制

乳酸菌群体感应系统研究进展()
分享到:

《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
18
期数:
2020年02期
页码:
141-149
栏目:
出版日期:
2020-03-30

文章信息/Info

Title:
Progress in quorum sensing system of lactic acid bacteria
文章编号:
1672-3678(2020)02-0141-09
作者:
逄晓阳朱青芦晶张书文刘浏杨兰李伟勋吕加平
中国农业科学院 农产品加工研究所,北京 100193
Author(s):
PANG XiaoyangZHU QingLU JingZHANG ShuwenLIU LiuYANG LanLI WeixunLü Jiaping
Institute of Food Science and Technology,Chinese Academy of Agricultural Science,Beijing 100193,China
关键词:
群体感应系统 信号分子 乳酸菌 生物学功能
分类号:
Q939.95;TS254.4
DOI:
10.3969/j.issn.1672-3678.2020.02.002
文献标志码:
A
摘要:
群体感应及其自我调控是细菌间进行信息交流的重要机制。细菌通过特定的化学信号分子来监测菌群密度和周围环境的变化,进而调节菌体内相关基因表达,使菌体更加适应周围环境。乳酸菌很多生物学现象都与群体感应系统有关。本文中,笔者总结了乳酸菌群体感应系统的组成、信号转导机制及其生物学功能,这些功能包括调控菌体生物膜的形成、菌株自溶、抗菌肽的合成、酸胁迫应答。本综述将为乳品工业提高乳酸菌的发酵密度和扩大其益生菌功能提供新思路。
Abstract:
Quorum sensing(QS)and its self-regulation is an important mechanism for the transmission of information among bacteria,to regulate the expression of the related bacteria genes to make them more adaptable to their environment through specific chemical signal molecules sensing the change of the bacteria density and surrounding environment.There are many biological phenomena in lactic acid bacteria related to the quorum sensing system.Here we review the composition of quorum sensing system in lactic acid bacteria,signal transduction mechanism and biological function including that regulating the biofilm formation,autolysis,antibiotics production and acid stress response.This review will provide new ideas in improving the fermentation density of lactic acid bacteria,as well as expanding their probiotic functions.

参考文献/References:

[1] LI B,HABERMANN D,KLICHE T,et al.Soluble Lactobacillus delbrueckii subsp. bulgaricus 92059 PrtB proteinase derivatives for production of bioactive peptide hydrolysates from casein[J].Appl Microbiol Biotechnol,2019,103(6):2731-2743.
[2] WANG C,CUI Y,QU X.Identification of proteins regulated by acid adaptation related two component system HPK1/RR1 in Lactobacillus delbrueckii subsp.bulgaricus[J].Arch Microbiol,2018,200(9):1381-1393.
[3] YIN X C,SALEMI M R,PHINNEY B S,et al.Proteomes of Lactobacillus delbrueckii subsp.bulgaricus LBB.B5 incubated in milk at optimal and low temperatures[J].mSystems,2017,2(5):e00027-17.
[4] LIU L,WU R Y,ZHANG J L,et al.Overexpression of luxS promotes stress resistance and biofilm formation of Lactobacillus paraplantarum L-ZS9 by regulating the expression of multiple genes[J].Front Microbiol,2018,9:2628.
[5] WASFI R,OLA A,RAHMAN A E,et al.Probiotic Lactobacillus sp.inhibit growth,biofilm formation and gene expression of caries-inducing Streptococcus mutans[J].Cell Mol Med,2018,22(3):1972-1983.
[6] PEZZULO A A,HORNICK E E,RECTOR M V,et al.Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster[J].PLoS ONE,2012,7(8):e43777.
[7] MEDELLIN M J,GRIFFITHS M W.Effect of molecules secreted by Lactobacillus acidophilus strain La-5 on Escherichia coli O157:H7 colonization[J].Appl Environ Microbiol,2009,75(4):1165-1172.
[8] PARK H,SHIN H,LEE K,et al.Autoinducer-2 properties of kimchi are associated with lactic acid bacteria involved in its fermentation[J] . Food Microbiol,2016,225:38-42.
[9] WILSON C M,AGGIOR B M,O’TOOLE P W,et al.Transcriptional and metabolomic consequences of LuxS inactivation reveal a metabolic rather than quorum-sensing role for luxS in Lactobacillus reuteri 100-23[J].J Bacteriol,2012,194(7):1743-1746.
[10] CAGNO R D,ANGELIES M D,CALASSO M,et al.Proteomics of the bacterial cross-talk by quorum sensing[J].Proteomics,2011,74(1):19-34.
[11] LUBKOWICZ D,HO C L,HWANG I Y,et al.Reprogramming probiotic Lactobacillus reuteri as a biosensor for Staphylococcus aureus derived AIP-I detection[J].ACS Synth Biol,2018,7(5):1229-1237.
[12] STURME M H J,FRANCKE C,SIEZEN R J,et al.Making sense of quorum sensing in lactobacilli:a special focus on Lactobacillus plantarum WCFS1[J].Microbiology,2007,153(12):3939-3947.
[13] DUARTE V S,CAMPANARO S,TREU L,et al.The complete genome sequence of Trueperella pyogenes UFV1 reveals a processing system involved in the quorum-sensing signal response[J].Genome Announc,2017,5(29):e00639-17.
[14] PARK H.Autoinducer-2 Quorum sensing influences viability of Escherichia coli O157:H7 under osmotic and in vitro gastrointestinal stress conditions[J].Front Microbiol,2017,8:1077.
[15] ZHAO J,QUAN C S,JIN L M,et al.Production,detection and application perspectives of quorum sensing autoinducer-2 in bacteria[J].J Biotechnol,2018,268:53-60.
[16] WAHEED H,XIAO Y Y,HASHMI I,et al.Insights into quorum quenching mechanisms to control membrane biofouling under changing organic loading rates[J].Chemosphere,2017,182:40-47.
[17] PANG X Y,LIU C P,LYU P C,et al.Identification of quorum sensing signal molecule of Lactobacillus delbrueckii subsp.bulgaricus[J].J Agric Food Chem,2016,64(49):9421-9427.
[18] VAN BELKUM M J,DERKSEN D J,FRANZ C M A P,et al.Structure function relationship of inducer peptide pheromones involved in bacteriocin production in Carnobacterium maltaromaticum and Enterococcus faecium[J].Microbiology,2007,153(11):3660-3666.
[19] VAUGHAN A,EIJSINK V G,VAN SINDEREN D.Functional characterization of a composite bacteriocin locus from malt isolate Lactobacillus sakei 5[J].Appl Environ Microbiol,2003,69(12):7194-7203.
[20] DIEP D B,SIGVE L,NES V I F,et al.A bacteriocin-like peptide induces bacteriocin synthesis in Lactobacillus plantarum C11[J].Mol Microbiol,1995,18(4):631-639.
[21] BRURBERG M B,Nes I F,EIJSINK V G.Pheromone-induced production of antimicrobial peptides in Lactobacillus[J].Mol Microbiol,1997,26(2):347-360.
[22] DIEP D B,AXELSSON L,GREFSLI C et al.The synthesis of the bacteriocin sakacin A is a temperature-sensitive process regulated by a pheromone peptide through a three-component regulatory system[J].Microbiology,2000,146(9):2155-2160.
[23] FLEUCHOT B,GITTON C,GUILLOT A,VIDIC J,et al.Rgg proteins associated with internalized small hydrophobic peptides:a new quorum-sensing mechanism in Streptococci[J].Mol Microbiol,2011,80(4):1102-1119.
[24] FONTAINE L,BOUTRY C,FRAHAN M H D,et al.A novel pheromone quorum-sensing system controls the development of natural competence in Streptococcus thermophilus and Streptococcus salivarius[J].J Bacteriol,2010,192(5):1444-1454.
[25] KLEEREBEZEM M,QUADRI L E N,KUIPERS O P,et al.Quorum sensing by peptide pheromones and two-component signal-transduction systems in gram-positive bacteria[J].Mol Microbiol,1997,24(5):895-904.
[26] SALAS-JARA M J,IIABACA A,VEGA M,et al.,Biofilm forming Lactobacillus:new challenges for the development of probiotics[J].Microorganisms,2016,4(3):35.
[27] LEBEER S,DE KEERSMAECKR S C J,AVEHOEVEN T L A,et al.Functional analysis of luxS in the probiotic strain Lactobacillus rhamnosus GG reveals a central metabolic role important for growth and biofilm formation[J].J Bacteriol,2007,189(3):860-871.
[28] BUCK B L,AZCARATE-PERIL M A,KLAENHAMMER T R.Role of autoinducer-2 on the adhesion ability of Lactobacillus acidophilus[J].Appl Microbiol,2009,107(1):269-279.
[29] ROUX A,TODD D A,VELAZQUEZ J V,et al.CodY-mediated regulation of the Staphylococcus aureus Agr system integrates nutritional and population density signals[J].J Bacteriol,2014,196(6):1184-1196
[30] STURME M H,NAKAYAMA J,MOLENAAR D,et al.An arg-like two-component regulatory system in Lactobacillus plantrum is involved in production of a novel cyclic peptide and regulation of adherence[J].J Bacteriol,2005,187(15):5224-5235
[31] CIBIK R,CHAPOT-CHARTIER M P.Autolysis of dairy leuconostocs and detection of peptidoglycan hydrolases by renaturing SDS-PAGE[J].Appl Microbiol,2000,89(5):862-869.
[32] ORTAKCI,BROADBENT F,OBERG J R et al.Late blowing of Cheddar cheese induced by accelerated ripening and ribose and galactose supplementation in presence of a novel obligatory heterofermentative nonstarter Lactobacillus wasatchensis[J].Dairy Sci,2015,98(11):7460-7472.
[33] LAZZI C,POVOLO M,LOCCI F,et al.Can the development and autolysis of lactic acid bacteria influence the cheese volatile fraction:the case of Grana padano[J].Food Microbiol,2016,233:20-28.
[34] SONDERGAARD L,RYSSEL M,SVENDSEN C et al.Impact of NaCl reduction in Danish semi-hard Samsoe cheeses on proliferation and autolysis of DL-starter cultures[J].Food Microbiol,2015,213:59-70.
[35] GARBOWSKA M,PLUTA A,BERTHOLD-PLUTA.Dipeptidase activity and growth of heat-treated commercial dairy starter culture[J] .Appl Biochem Biotechnol,2015,175(5):2602-2615.
[36] WILLIAMS A G,WHITER S E,BRECHANY E Y,et al.Glutamate dehydrogenase activity in lactobacilli and the use of glutamate dehydrogenase-producing adjunct Lactobacillus spp.cultures in the manufacture of cheddar cheese[J].Appl Microbiol,2006,101(5):1062-1075.
[37] XU Y,KONG J.Construction and potential application of controlled autolytic systems for Lactobacillus casei in cheese manufacture[J] . Food Prot,2013,76(7):1187-1193.
[38] VISWESWARAN G R R,KUREK D,SZELIGA M,et al.Expression of prophage-encoded endolysins contributes to autolysis of Lactococcus lactis[J].Appl Microbiol Biotechnol,2017,101(3):1099-1110.
[39] COLLINS Y F,MCSWEENEY P L,WILKINSON M G.Evidence of a relationship between autolysis of starter bacteria and lipolysis in cheddar cheese during ripening[J].Dairy Res,2003,70(1):105-13.
[40] PANG X Y,CUI W M,LIU L,et al.Gene knockout and overexpression analysis revealed the role of N-acetylmuramidase in autolysis of Lactobacillus delbrueckii subsp.bulgaricus ljj-6[J].PLoS ONE,2014,9(8):e104829.
[41] CUI Y H,LIU W,QU X J,et al.A two component system is involved in acid adaptation of Lactobacillus delbrueckii subsp.bulgaricus[J].Microbiol Res,2012,167(5):253-261.
[42] El-SHAROUD W.Two-component signal transduction systems as key players in stress responses of lactic acid bacteria[J].Sci Prog,2005,88(4):203-228.
[43] THEVENARD B,ROSOAVA N,FOURCASSIE P,et al.Characterization of Streptococcus thermophilus two-component systems:in silico analysis,functional analysis and expression of response regulator genes in pure or mixed culture with its yogurt partner,Lactobacillus delbrueckii subsp.bulgaricus[J].Food Microbiol,2011,151(2):171-181.
[44] ZUNIGA M,GOMEZ-ESCOIN C,GONZALEZ-CANDELAS F.Evolutionary history of the OmpR/IIIA family of signal transduction two component systems in Lactobacillaceae and Leuconostocaceae[J].BMC Evol Biol,2011,11:34.
[45] BORLAND S,OUDART A,PRIGENT-COMBARET C,et al.Genome-wide survey of two-component signal transduction systems in the plant growth-promoting bacterium Azospirillum[J].BMC Genom,2015,16:833.
[46] MARX P,MEIERS M,BRUCKNER R.Activity of the response regulator CiaR in mutants of Streptococcus pneumoniae R6 altered in acetyl phosphate production[J].Front Microbiol,2014,5:772.
[47] PANG X Y,ZHANG S W,LU J,et al,Identification and functional validation of autolysis associated genes in Lactobacillus bulgaricus ATCC BAA-365[J].Front Microbiol,2017,8:1367.
[48] 满丽莉,孟祥晨,王辉,等,群体感应系统在乳酸菌产细菌素中的作用[J].食品科学,2011,32(13):360-364.
[49] MOSLEHI-JENABIAN S,GORI K,JESPERSEN L.AI-2 signalling is induced by acidic shock in probiotic strains of Lactobacillus spp[J].Food Microbiol,2009,135(3):295-302.
[50] RORERS P D,LIU T T,BARKER K S,et al.Gene expression profiling of the response of Streptococcus pneumoniae to penicillin[J].J Antimicrob Chemother,2007,59(4):616-626.

相似文献/References:

[1]赵辉,马文静,张应杰,等.基于天然产物的群体感应抑制剂的研究进展[J].生物加工过程,2019,17(03):300.[doi:10.3969/j.issn.1672-3678.2019.03.011]
 ZHAO Hui,MA Wenjing,ZHANG Yingjie,et al.A comprehensive review update and future trends of natural products as quorum sensing inhibitors[J].Chinese Journal of Bioprocess Engineering,2019,17(02):300.[doi:10.3969/j.issn.1672-3678.2019.03.011]
[2]陈天鹏,朱家庆,柳东,等.基于微生物群体感应的固定化研究进展[J].生物加工过程,2020,18(02):170.[doi:10.3969/j.issn.1672-3678.2020.02.005]
 CHEN Tianpeng,ZHU Jiaqing,LIU Dong,et al.Research progress in immobilized fermentation based on quorum sensing[J].Chinese Journal of Bioprocess Engineering,2020,18(02):170.[doi:10.3969/j.issn.1672-3678.2020.02.005]
[3]夏凯,钱成巩,梁新乐.醋杆菌中群体感应分布与遗传进化分析[J].生物加工过程,2020,18(02):245.[doi:10.3969/j.issn.1672-3678.2020.02.014]
 XIA Kai,QIAN Chenggong,LIANG Xinle.Phylogenetic and distributional analysis of quorum sensing in Acetobacter[J].Chinese Journal of Bioprocess Engineering,2020,18(02):245.[doi:10.3969/j.issn.1672-3678.2020.02.014]
[4]张天震,刘伶普,李文超,等.群体感应系统介导细菌生物膜形成的研究进展[J].生物加工过程,2020,18(02):177.[doi:10.3969/j.issn.1672-3678.2020.02.006]
 ZHANG Tianzhen,LIU Lingpu,LI Wenchao,et al.Advances in quorum sensing regulating formation of biofilm[J].Chinese Journal of Bioprocess Engineering,2020,18(02):177.[doi:10.3969/j.issn.1672-3678.2020.02.006]

备注/Memo

备注/Memo:
收稿日期:2019-12-21修回日期:2020-01-16
基金项目:国家自然科学基金(31871833、31471603); 国家重点研发计划(2017YFC1600903)
作者简介:逄晓阳(1980—),男,山东烟台人,博士,副研究员,研究方向:乳酸菌生物技术; E-mail:pangxiaoyang@163.com; ORCID 0000-0003-1813-2039
引文格式:逄晓阳,朱青,芦晶,等.乳酸菌群体感应系统研究进展[J].生物加工过程,2020,18(2):141-149.
PANG Xiaoyang,ZHU Qing,LU Jing,et al.Progress in quorum sensing system of lactic acid bacteria[J].Chin J Bioprocess Eng,2020,18(2):141-149..
更新日期/Last Update: 2020-03-31