|本期目录/Table of Contents|

[1]陈雪鋆,吕琛,范茗,等.智能磁力驱动自愈合水凝胶的制备及性能研究[J].生物加工过程,2018,16(05):71-79.[doi:10.3969/j.issn.1672-3678.2018.05.010]
 CHEN Xueyun,LV Chen,FAN Ming,et al.Preparation and evaluation of intelligent self-healing hydrogel encapsulated magnetic gelatin microspheres[J].Chinese Journal of Bioprocess Engineering,2018,16(05):71-79.[doi:10.3969/j.issn.1672-3678.2018.05.010]
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智能磁力驱动自愈合水凝胶的制备及性能研究()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
16
期数:
2018年05期
页码:
71-79
栏目:
出版日期:
2018-09-29

文章信息/Info

Title:
Preparation and evaluation of intelligent self-healing hydrogel encapsulated magnetic gelatin microspheres
文章编号:
1672-3678(2018)05-0071-09
作者:
陈雪鋆吕琛范茗谈华平
南京理工大学 材料科学与工程学院,江苏 南京 210094
Author(s):
CHEN XueyunLV ChenFAN MingTAN Huaping
School of Materials Science and Engineering,Nanjing University of Science and Technology,Nanjing 210094,China
关键词:
自愈合 智能水凝胶 席夫碱反应 组织工程 生物医用材料
分类号:
TB341;O648.1
DOI:
10.3969/j.issn.1672-3678.2018.05.010
文献标志码:
A
摘要:
笔者研究了一种包裹磁性微球的动态可注射复合水凝胶,用于药物传递和抗肿瘤治疗。其中,水凝胶由水溶性羧乙基壳聚糖(CEC)和氧化海藻酸盐(OAlg)通过席夫碱反应(Schiff-base)进行交联而制成,具有良好的自愈性。为了增强水凝胶的力学性能和生物降解能力,采用乳化交联法制备了载有5-氟尿嘧啶(5-Fu)的磁性明胶微球(MGMs),并包埋入水凝胶中。对该复合水凝胶的磁性能、溶胀性能、降解率和流变性能等特性进行测试,以比较不同浓度的MGMs在水凝胶中的性能差异。综合各种因素发现:30 mg/mL的MGMs/水凝胶具有最佳性能,并且在生理条件下,由于动态的席夫碱反应,再交联过程表现出良好的自愈能力。在体外药物释放试验中,MGMs/水凝胶与单独的MGMs和空白水凝胶相比,表现出最佳的5-Fu缓释性。因此,基于CEC/OAlg包埋的有5-Fu/MGMs动态自愈合水凝胶在药物传递和各种生物医学领域有良好的应用前景。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2018-05-30修回日期:2018-06-08
基金项目:中央高校基本科研专项资金(AE16001)
作者简介:陈雪鋆(1994—),女,江苏张家港人,硕士研究生,研究方向:生物医用材料; 谈华平(联系人),教授,E-mail:hptan@njust.edu.cn
引文格式:陈雪鋆,吕琛,范茗,等.智能磁力驱动自愈合水凝胶的制备及性能研究[J].生物加工过程,2018,16(5):71-79.
CHEN Xueyun,LV Chen,FAN Ming,et al.Preparation and evaluation of intelligent self-healing hydrogel encapsulated magnetic gelatin microspheres[J].Chin J Bioprocess Eng,2018,16(5):71-79..
更新日期/Last Update: 2018-09-30