|本期目录/Table of Contents|

[1]冯鹏程,王佳玲,李媛媛,等.上转换纳米颗粒在肿瘤诊断与治疗中的研究进展[J].生物加工过程,2018,16(05):1-10.[doi:10.3969/j.issn.1672-3678.2018.05.001]
 FENG Pengcheng,WANG Jialing,LI Yuanyuan,et al.Research progress in the application of upconversion nanoparticles for cancer diagnosis and treatment[J].Chinese Journal of Bioprocess Engineering,2018,16(05):1-10.[doi:10.3969/j.issn.1672-3678.2018.05.001]
点击复制

上转换纳米颗粒在肿瘤诊断与治疗中的研究进展()
分享到:

《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
16
期数:
2018年05期
页码:
1-10
栏目:
出版日期:
2018-09-29

文章信息/Info

Title:
Research progress in the application of upconversion nanoparticles for cancer diagnosis and treatment
文章编号:
1672-3678(2018)05-0001-10
作者:
冯鹏程1王佳玲1李媛媛2张荣露2陶佩2周敏1朱静怡1缪文俊1黄和1
1.南京工业大学 药学院,江苏 南京 211800; 2.南京工业大学 生物与制药工程学院,江苏 南京 211800
Author(s):
FENG Pengcheng1WANG Jialing1LI Yuanyuan2ZHANG Ronglu2TAO Pei2ZHOU Min1ZHU Jingyi1MIAO Wenjun1HUANG He1
1. School of Pharmaceutical Sciences,Nanjing Tech University,Nanjing 211800,China; 2. College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211800,China
关键词:
上转换纳米颗粒 光疗法 化学联合疗法 肿瘤诊疗一体化 生物医用材料
分类号:
Q631;TQ422
DOI:
10.3969/j.issn.1672-3678.2018.05.001
文献标志码:
A
摘要:
上转换纳米颗粒具备光学/化学稳定性高、生物毒性低、荧光寿命长及激发光生物组织穿透深度较大等显著优点,近年来在生物传感、生物成像和疾病治疗等生物医学领域的研究和应用获得了广泛的关注。本文中,笔者就稀土元素掺杂的上转换纳米颗粒在肿瘤的诊断与治疗方面的研究现状及进展进行综合概述,主要对其在光动力疗法(PDT)、光热疗法(PPT)、化学联合疗法及多模态诊疗一体化等方面的研究展开分析和讨论,为上转换纳米颗粒的进一步研究开发及临床应用提供新的参考方向及思路。

参考文献/References:

[1] 杨柯君.全球癌症状况最新数据更新[J].上海医药,2014(2):5.
[2] 王燕,孙燕.肿瘤靶向治疗现状和发展前景[J].中华肿瘤杂志,2005,27(10):638-640.
[3] LIU C,HOU Y,GAO M.Are rare-earth nanoparticles suitable for in vivo applications[J].Adv Mater,2015,26(40):6922-6932.
[4] YANG D,MA P,HOU Z,et al.Current advances in lanthanide ion(Ln3+)-based upconversion nanomaterials for drug delivery[J].Chem Soc Rev,2015,44(6):1416-1448.
[5] CHANG H,HUANG L,HUANG W,et al.Rare earth ion-doped upconversion nanocrystals:synthesis and surface modification[J].Nanomaterials,2015,5(1):1-25.
[6] LIN M,XU F,LU T,et al.Recent advances in synthesis and surface modification of lanthanide-doped upconversion nanoparticles for biomedical applications[J].Biotech Adv,2012,30(6):1551-1561.
[7] CHEN G,QIU H,CHEN X,et al.Upconversion nanoparticles:design,nanochemistry,and applications in theranostics[J].Chem Rev,2014,114(10):5161-5214.
[8] PARK Y I,SUH Y D,HYEON T,et al.Upconverting nanoparticles:a versatile platform for wide-field two-photon microscopy and multi-modal in vivo imaging[J].Chem Soc Rev,2015,44(6):1302-1317.
[9] YI G,PENG Y,GAO Z.Strong red-emitting near-infrared-to-visible upconversion fluorescent nanoparticles[J].Chem Mater,2011,23(11):2729-2734.
[10] AUZEL F.Upconversion and anti-Stokes processes with f and d ions in solids[J].Chem Rev,2004,104:139-173.
[11] FANG W,WEI Y.Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy[J].J Innov Opt Heal Sci,2016,9(4):1630006.
[12] 吴靓,肖双喜,许剑平,等.稀土掺杂上转换发光纳米材料及其在生物分析化学的应用[J].功能材料,2017,48(5):5028-5036.
[13] 王霞,胡辉,白燕.Li+掺杂对TeO2:Tm3+/Er3+/Yb3+纳米材料上转换发光的增强作用[J].无机化学学报,2013,29(4):659-664.
[14] 胡荣璇,王慧云,郑彤,等.Gd3+掺杂对NaYF4:Yb3+,Tm3+/Er3+纳米材料上转换荧光性能的影响[J].发光学报,2015,36(1):20-26.
[15] 刘珊珊,徐征,赵谡玲,等.氟离子浓度对稀土掺杂上转换发光纳米材料形貌及荧光寿命的影响[J].物理化学学报,2016,32(8):2108-2112.
[16] LI C,LIN J.Rare earth fluoride nano-/microcrystals:synthesis,surface modification and application[J].J Mater Chem,2010,20(33):6831-6847.
[17] SU J,ZHANG Q L,SHAO S F,et al.Phase transition,structure and luminescence of Eu:YAG nanophosphors by co-precipitation method[J].J Alloy Compd,2009,470(1):306-310.
[18] YIN A,ZHANG Y,YAN Z H,et al.Colloidal synthesis and blue based multicolor upconversion emissions of size and composition controlled monodisperse hexagonal NaYF4:Yb,Tm nanocrystals[J].Nanoscale,2010,2(6):953-959.
[19] WANG G F,PENG Q,LI Y D.Lanthanide-doped nanocrystals:synthesis,optical-magnetic properties,and applications[J].Acc Chem Res,2011,44(5):322-332.
[20] 王玉凤,李隆敏,许桐瑛,等.上转换纳米材料在光动力疗法中的研究进展[J].现代肿瘤医学,2017,25(9):1489-1492.
[21] 潘育松,丁洁.上转换纳米材料在肿瘤治疗中的应用[J].广州化工,2016,44(12):33-34.
[22] 刘晓不殆,屈亚威,刘海峰.上转换纳米材料在光动力治疗中的应用进展[J].武警医学,2017,28(4):393-396.
[23] FENG L,HE F,DAI Y,et al.Multifunctional UCNPs@MnSiO3@g-C3N4 nanoplatform:improved ROS generation and reduced glutathione levels for highly efficient photodynamic therapy[J].Biomater Sci,2017,5(12):2456-2467.
[24] 焦体峰,黄欣欣,张乐欣,等.光热剂/光敏剂纳米材料合成及应用研究进展[J].燕山大学学报,2017,41(3):189-203.
[25] WANG M,CHEN Z,ZHENG W,et al.Lanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy[J].Nanoscale,2014,6(14):8274-8282.
[26] TIAN G,REN W,YAN L,et al.Red-emitting upconverting nanoparticles for photodynamic therapy in cancer cells under near-infrared excitation[J].Small,2013,9(11):1929-1938.
[27] HOU Z,ZHANG Y,DENG K,et al.UV-emitting upconversion-based TiO2photosensitizing nanoplatform:near-Infrared light mediated in vivo photodynamic therapy via mitochondria-involved apoptosis pathway[J].ACS Nano,2015,9(3):2584-2599.
[28] 胡鹤.稀土上转换发光纳米材料的制备及其在生物医学成像中的应用[D].上海:复旦大学,2009.
[29] LIU K,LIU X,ZENG Q,et al.Covalently assembled NIR nanoplatform for simultaneous fluorescence imaging and photodynamic therapy of cancer cells[J].ACS Nano,2012,6(5):4054-4062.
[30] HOU Z,DENG K,LI C,et al.808 nm light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd3+-sensitized upconversion emission with enhanced anti-tumor efficacy[J].Biomaterials,2016,101:32-46.
[31] LIU S,YUAN Y,YANG Y,et al.Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy[J].J Mater Chem B,2017,5(41):8169-8177.
[32] ZHAO N,WU B,HU X,et al.NIR-triggered high-efficient photodynamic and chemo-cascade therapy using caspase-3 responsive functionalized upconversion nanoparticles[J].Biomaterials,2017,141:40-49.
[33] CHEN Y,ZHANG F,WANG Q,et al.Near-infrared light-mediated LA-UCNPs@SiO2-C/HA@mSiO2-DOX@NB nanocomposite for chemotherapy/PDT/PTT and imaging[J].Dalton Trans,2017,46:14293-14300.
[34] 张金中,NADEJDA R.基于金属纳米材料的癌症光热切除疗法[J].中国科学:化学,2009,39(10):1285.
[35] TIAN Q,TANG M,SUN Y,et al.Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells[J].Adv Mater,2011,23(31):3542-3547.
[36] TIAN Q,JIANG F,ZOU R,et al.Hydrophilic Cu9S5 nanocrystals:a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo[J].ACS Nano,2011,5(12):9761-9771.
[37] CHEN CJ,CHEN DH.Preparation of LaB6 nanoparticles as a novel and effective near-infrared photothermal conversion material[J].Chem Eng J,2012,180(6):337-342.
[38] QIAN L P,ZHOU L H,TOO H P,et al.Gold decorated NaYF4:Yb,Er/NaYF4 /silica(core/shell/shell)upconversion nanoparticles for photothermal destruction of BE(2)-C neuroblastoma cells[J].J Nanopart Res,2011,13(2):499-510.
[39] RONG T,CHEN X,LI Q,et al.An electrochemical aptasensor electrocatalysts for detection of thrombin[J].Anal Biochem,2016,500:73-79.
[40] SHAO Q,OUYANG L,JIN L,et al.Multifunctional nanoheater based on NaGdF4:Yb3+,Er3+ upconversion nanoparticles[J].Opt Express,2015,23(23):30057-30066.
[41] HU F,YUAN Y,MAO D,et al.Smart activatable and traceable dual-prodrug for image-guided combination photodynamic and chemo-therapy[J].Biomaterials,2017,144:53-59.
[42] WARD MD.Photo-induced electron and energy transfer in non-covalently bonded supramolecular assemblies[J].Chem Soc Rev,1997,26(5):365-375.
[43] DING D,LI K,LIU B,et al.Bioprobes based on AIE fluorogens[J].Acc Chem Res,2013,46(11):2441-2453.
[44] LIU F,HE X,LEI Z,et al.Facile preparation of doxorubicin-loaded upconversion@polydopamine nanoplatforms for simultaneous in vivo multimodality imaging and chemophotothermal synergistic therapy[J].Adv Healthcare Mater,2015,4(4):559-568.
[45] FENG L,GAI S,HE F,et al.Multifunctional mesoporous ZrO2 encapsulated upconversion nanoparticles for mild NIR light activated synergistic cancer therapy[J].Biomaterials,2017,147:39-52.
[46] CEN Y,DENG W J,YANG Y,et al.A Core-Shell-Shell multifunctional nanoplatform for intracellular tumor-related mRNAs imaging and near-infrared light triggered photodynamic-photothermal synergistic therapy[J].Anal Chem,2017,89(19):10321-10328.
[47] 陈颖,朱明华.液态活检技术的发展及肿瘤领域的应用[J].分子诊断与治疗杂志,2015,7(6):361-366.
[48] 徐金,陈学元.基于稀土氟氧化物纳米荧光标记的前列腺特异性抗原超灵敏体外检测[C]//中国化学会.第十四届固态化学与无机合成学术会议论文摘要集,2016.
[49] 华东,吴世嘉,王周平,等.基于抗体功能化磁性纳米材料和上转换荧光纳米材料检测癌胚抗原的试剂盒:102636649A[P].2012-03-04.
[50] SUN N,WANG J,JI L,et al.A cellular compatible chitosan nanoparticle surface for Isolation and in situ culture of rare number CTCs[J].Small,2015,11(40):5444-5451.
[51] SHUAI F,CHAO W,RUI P,et al.Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells[J].J Nano Res,2014,7(9):1327-1336.
[52] 朱瑾,夏刚强,罗芳,等.基于上转换发光纳米材料NaYF_4:Yb,Er的免疫层析试纸条测定血清中的降钙素原[J].理化检验(化学分册),2016,52(5):501-505.
[53] PENG J,SAMANTA A,ZENG X,et al.Real-time in vivo hepatotoxicity monitoring through chromophore-conjugated photon-upconverting nanoprobes[J].Angew Chem Int Ed,2017,56(15):4165-4169.
[54] LI Z,LV S,WANG Y,et al.Construction of LRET-based nanoprobe using upconversion nanoparticles with confined emitters and bared surface as luminophore[J].J Am Chem Soc,2015,137(9):3421-3427.
[55] 刘映,胡益辉,彭俊梅.基于上转换纳米材料的pH传感器研究[J].科技资讯,2015,13(20):102-103.
[56] WANG D,XUE B,KONG X,et al.808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging[J].Nanoscale,2015,7(1):190-197.

备注/Memo

备注/Memo:
收稿日期:2017-12-27修回日期:2018-04-06
基金项目:国家自然科学基金(51603101); 国家重点研发计划(2016YFC1201500); 江苏省高校自然科学计划面上项目(16KJB350001、17KJB350005); 南京工业大学校内自选课题(ZKRC201515)
作者简介:冯鹏程(1996—),女,江西九江人,硕士研究生,研究方向:纳米生物材料; 缪文俊(联系人),副教授,E-mail:miaowj@njtech.edu.cn; 黄 和(联系人),教授,E-mail:huangh@njtech.edu.cn
引文格式:冯鹏程,王佳玲,李媛媛,等.上转换纳米颗粒在肿瘤诊断与治疗中的研究进展[J].生物加工过程,2018,16(5):1-10.
FENG Pengcheng,WANG Jialing,LI Yuanyuan,et al.Research progress in the application of upconversion nanoparticles for cancer diagnosis and treatment[J].Chin J Bioprocess Eng,2018,16(5):1-10..
更新日期/Last Update: 2018-09-30