|本期目录/Table of Contents|

[1]杨忠华,曾嵘,姚善泾,等.不对称还原前手性芳香酮微生物的筛选及反应特性[J].生物加工过程,2008,6(01):32-36.[doi:10.3969/j.issn.1672-3678.2008.01.007]
 YANG Zhong-hua,ZENG Rong,YAO Shan-jing,et al.Screening of microbe for asymmetric reduction of prochiral aryl ketones and characterization of the reduction reaction[J].Chinese Journal of Bioprocess Engineering,2008,6(01):32-36.[doi:10.3969/j.issn.1672-3678.2008.01.007]
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不对称还原前手性芳香酮微生物的筛选及反应特性()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
6
期数:
2008年01期
页码:
32-36
栏目:
出版日期:
2008-01-30

文章信息/Info

Title:
Screening of microbe for asymmetric reduction of prochiral aryl ketones and characterization of the reduction reaction
作者:
杨忠华1曾嵘2姚善泾3吕早生1伍林1
1. 武汉科技大学, 化学工程与技术学院, 武汉, 430081; 2. 湖北大学, 化学化工学院, 武汉, 430061; 3. 浙江大学, 化学工程与生物工程学系, 杭州, 310027
Author(s):
YANG Zhong-hua1 ZENG Rong2 YAO Shan-jing3 LU Zao-sheng1 WU Lin1
关键词:
芳香酮不对称手性还原白地霉
分类号:
TQ203.2
DOI:
10.3969/j.issn.1672-3678.2008.01.007
摘要:
含芳香基手性醇是许多手性药物合成的关键手性砌块,生物催化不对称还原前手性酮是合成该类醇的重要方法之一.以4’-氯-苯乙酮为模型底物,从土壤中筛选得到一株能高效催化前手性芳香酮不对称还原合成相应手性醇的菌株,鉴定表明该菌株为白地霉( Geotrichum candid ).进一步考察了其催化4’-氯-苯乙酮不对称还原的反应特性,发现还原4’-氯-苯乙酮的产物主要为 S-4’-氯苯乙醇.在合适的反应条件下,其产率达到35%,对映选择性高于97%.

参考文献/References:

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[5] 张毅立, 廖建, 陈代谟. 苯乙醇胺类药物的不对称合成 [J]. 化学研究与应用, 1999(5):480-483.
[6] McCoy M. Biocatalysis grows for drug synthesis [J]. Chemical and Engineering News, 1999(1):10-13.
[7] Yang Z H, Yao S J, Lin D Q. Improving the stereoselectivity of asymmetric reduction of 3-oxo ester to 3-hydroxy ester with pretreatments on bakers’ yeast [J]. Industrial and Engineering Chemistry Research, 2004, (16):4871-4875.doi:10.1021/ie034240+.
[8] Nakamura K, Yamanaka R, Matsudab T. Recent developments in asymmetric reduction of ketones with biocatalysts [J]. Tetrahedron:Asymmetry, 2003, (18):2659-2681.
[9] 杨忠华, 梅乐和, 姚善泾. 面包酵母在催化不对称合成中的应用 [J]. 化学通报(印刷版), 2004(6):425-432.doi:10.3969/j.issn.0441-3776.2004.06.009.
[10] 刘湘, 方志杰, 许建和. 酵母细胞催化芳香酮的不对称还原反应 [J]. 催化学报, 2006(1):20-24.doi:10.3321/j.issn:0253-9837.2006.01.006.
[11] 杨忠华, 姚善泾, 王光辉. 引入树脂吸附促进酵母细胞不对称还原芳香酮 [J]. 化工学报, 2006, (10):2388-2392.doi:10.3321/j.issn:0438-1157.2006.10.023.
[12] 欧志敏. 微生物法还原羰基化合物制备手性药物中间体的研究 [D]. 杭州:浙江大学, 2002.32-35.
[13] Nakamura K, Matsuda T. Asymmetric reduction of ketones by the acetone powder of Geotrichum candidum [J]. Journal of Organic Chemistry, 1998, (24):8957-8964.doi:10.1021/jo9812779.

相似文献/References:

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备注/Memo

备注/Memo:
基金项目:教育部高等学校博士学科点专项科研基金,湖北省武汉市青年科技晨光计划,武汉科技大学校科研和教改项目
更新日期/Last Update: 1900-01-01