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[1]宋明媚,鞠培培,曹建军,等.化学法合成RGD三肽的研究[J].生物加工过程,2005,3(02):23-26.[doi:10.3969/j.issn.1672-3678.2005.02.005]
 SONG Ming-mei,JU Peipei,CAO Jian-jun,et al.Study on the synthesis of RGD tri-peptide by the chemical method[J].Chinese Journal of Bioprocess Engineering,2005,3(02):23-26.[doi:10.3969/j.issn.1672-3678.2005.02.005]
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化学法合成RGD三肽的研究()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
3
期数:
2005年02期
页码:
23-26
栏目:
出版日期:
2005-05-30

文章信息/Info

Title:
Study on the synthesis of RGD tri-peptide by the chemical method
作者:
宋明媚鞠培培曹建军沈树宝
南京工业大学, 制药与生命科学学院, 南京, 210009
Author(s):
SONG Ming-mei JU Peipei CAO Jian-jun SHEN Shu-bao
关键词:
RGD二环己基碳二亚胺混合酸酐法
分类号:
O629.72
DOI:
10.3969/j.issn.1672-3678.2005.02.005
摘要:
采用二环己基碳二亚胺法(DCC)合成了二肽Gly-Asp(OBzl)2,然后利用混合酸酐法得到全保护RGD三肽:Boc-Arg(NO2)-Gly-Asp(OBzl)2三肽;最后在Pd/C的催化加氢下,将保护基一起脱掉而得到RGD三肽的粗品.具体研究了合成二肽及三肽的主要影响因素及其优化条件.在优化条件下,获得三肽的结晶干品,总得率为57.2%.

参考文献/References:

[1] Samanen J. Development of a small RGD peptide fibrinogen receptorgon-ist with potent antiaggregatory activity in vitro [J]. Journal of Medicinal Chemistry, 1991.3114-3116.doi:10.1021/jm00114a022.
[2] Sow MA, Molla A. Synthesis of RGD amphiphilic cyclic peptide as fibrinogen or fibrinogen or fibronectin antagonist [J]. Journal of Lett Pept Sci, 1997.455-461.
[3] Gibsin C, Goodman S. Novel solid phase synthesis of azapeptides and azapeptidoids via fmoc strategy and its application in the synthesis of RGD-mimetic [J]. Journal of Organic Chemistry, 1999, (20):7388-7394.
[4] Ramachandran J, Li CH. Preparation of crystalline NG-Toslargimine derivatives [J]. Journal of Organic Chemistry, 1962, (27):4006-4008.
[5] Klaus HM, William DP. Studies on polypeptides [J]. Journal of Organic Chemistry, 1956, (78):238-242.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金,江苏省自然科学基金,江苏省社会发展基金,国家高技术研究发展计划(863计划)
更新日期/Last Update: 1900-01-01